4-Iodobenzenesulfonyl chloride → 2,4-Dimethyl-1-[3-(4-iodobenzenesulphonamido)propyl]pyrrolidine

HRID 1731539Notes

Reaction equation

HRID 1731539 reaction equation
[CH3:1][CH:2]1[CH2:6][CH:5]([CH3:7])[CH2:4][N:3]1[CH2:8][CH2:9][CH2:10][NH2:11].[I:12][C:13]1[CH:18]=[CH:17][C:16]([S:19](Cl)(=[O:21])=[O:20])=[CH:15][CH:14]=1>C1C=CC=CC=1>[CH3:1][CH:2]1[CH2:6][CH:5]([CH3:7])[CH2:4][N:3]1[CH2:8][CH2:9][CH2:10][NH:11][S:19]([C:16]1[CH:17]=[CH:18][C:13]([I:12])=[CH:14][CH:15]=1)(=[O:21])=[O:20]

Participants

4

Reactant 2

HCID 73994-Iodobenzenesulfonyl chlorideHCID 202277352,4-Dimethyl-1-(3-aminopropyl)pyrrolidine

Product 1

HCID 202277342,4-Dimethyl-1-[3-(4-iodobenzenesulphonamido)propyl]pyrrolidine

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A solution of 2,4-dimethyl-1-(3-aminopropyl)pyrrolidine (4.7 g, 0.03 mol) in benzene (20 ml) was added dropwise to a solution of 4-iodobenzenesulphonylchloride (9.1 g, 0.03 mol) benzene (80 ml). After stirring the resulting mixture for six hours at room temperature, the reaction product separated as an oil. The reaction mixture was evaporated, and the residue was dissolved in absolute alcohol (800 ml) and boiled with charcoal.

Workup

  1. customthe reaction product separated as an oil
  2. customThe reaction mixture was evaporated
  3. dissolutionthe residue was dissolved in absolute alcohol (800 ml)

Sources & evidence

ORD record
ord-b77c169c5c294ce2b97a2b090445d4d5
Source dataset
uspto-grants-1986_11
Patent number
US04622331

Reaction notes

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