反应详情

A solution of N-[2-(4-methoxyphenyl)ethyl]-2-hydroxy-1-oxo-2-(3-chlorophenyl)ethanamine (2.8 g) in dry tetrahydrofuran (20 ml) was added slowly to a refluxing suspension of lithium aluminium hydride (1.36 g) in tetrahydrofuran (30 ml) at reflux and then heated under reflux for 24 hours. After careful addition of water (1.4 ml), aqueous sodium hydroxide (10%; 1.4 ml) and water (2.8 ml), filtration and evaporation of the filtrate gave the crude product. Recrystallisation from ethyl acetate-hexane gave N-[2-(4-methoxyphenyl)-ethyl]-2-hydroxy-2-(3-chlorophenyl)ethanamine, mp 101°-3° C.

1. temperatureat reflux
2. temperatureheated
3. temperatureunder reflux for 24 hours
4. customgave the crude product
5. customRecrystallisation from ethyl acetate-hexane