2-Amino-1-(3-chlorophenyl)ethan-1-ol → HCID 20227982, compound

HRID 1731580Notes

Reaction equation

HRID 1731580 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:11][C:12](=O)[CH3:13])[CH:5]=[C:6]([F:10])[C:7]=1[O:8][CH3:9].[OH:15][CH:16]([C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=1)[CH2:17][NH2:18]>>[ClH:25].[F:1][C:2]1[CH:3]=[C:4]([CH2:11][CH:12]([NH:18][CH2:17][CH:16]([OH:15])[C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=2)[CH3:13])[CH:5]=[C:6]([F:10])[C:7]=1[O:8][CH3:9]

Participants

3

Reactant 2

HCID 37516012-Amino-1-(3-chlorophenyl)ethan-1-olHCID 18628161HCID 18628161, compound

Product 1

HCID 20227982HCID 20227982, compound

Procedure

N-[2-(3,5-difluoro-4-methoxyphenyl)-1-methylethyl]-2-hydroxy-2-(3-chlorophenyl)ethanamine hydrochloride, m.p. 120°-140° C. was prepared from 1-(3,5-difluoro-4-methoxyphenyl)propan-2-one (500 mg) and 2-hydroxy-2-(3-chlorophenyl)ethanamine (430 mg) as a 44:56 mixture of diastereoisomers, by an analogous procedure to that described in Example 1.

Sources & evidence

ORD record
ord-5f5d363672fb4183842459756cd28ab8
Source dataset
uspto-grants-1986_11
Patent number
US04622342

Reaction notes

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