Hydrochloric Acid → HCID 178512899, compound

HRID 1731592Notes

Reaction equation

HRID 1731592 reaction equation
[NH:1](C(OC(C)(C)C)=O)[CH2:2][C:3]([NH:5][C@H:6]([C:14]([OH:16])=[O:15])[CH2:7][CH2:8][CH2:9][NH:10][C:11](=[NH:13])[NH2:12])=[O:4].Cl.Cl.CC(O)=O>CO>[NH2:1][CH2:2][C:3]([NH:5][C@H:6]([C:14]([OH:16])=[O:15])[CH2:7][CH2:8][CH2:9][NH:10][C:11](=[NH:12])[NH2:13])=[O:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 22641269Acetate-hydrochloric acidHCID 178453838HCID 178453838, compound

Product 1

HCID 178512899HCID 178512899, compoundYield 189.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

125.7 Grams (0.25 mol) of BOC-Gly-Arg-CHA.HCl was dissolved in a small quantity of MeOH and to the solution was added with 500 ml of 2N-HCl/AcOH and the mixture was reacted under stirring at room temperature for 1 hour. After the reaction was completed, the reaction mixture was reprecipitated in 4.5 liters of diethyl ether and the crystals precipitated were collected by filtration and dried to obtain 109.8 g (100%) of H-Gly-Arg-CHA.2HCl. Rf3 =0.09. Melting point: 219.5° C. (decomposed). [α]D20 -21.0 (C=1, AcOH:H2O=1:1).

Workup

  1. customthe mixture was reacted
  2. customthe reaction mixture was reprecipitated in 4.5 liters of diethyl ether
  3. customthe crystals precipitated
  4. filtrationwere collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-42ddfa440b374b24bff34751d2735b01
Source dataset
uspto-grants-1986_11
Patent number
US04622389

Reaction notes

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