Potassium Hydroxide → HCID 13746694, compound

HRID 1731630Notes

Reaction equation

HRID 1731630 reaction equation
[CH2:1]1[C:23]2[C:4](=[CH:5][C:6]3[S:12](=[O:13])[C:11]4[CH:14]=[C:15]([C:18]([O:20]C)=[O:19])[CH:16]=[CH:17][C:10]=4[CH2:9][CH2:8][C:7]=3[CH:22]=2)[CH2:3][CH2:2]1.[OH-].[K+]>O.C(O)C>[CH2:1]1[C:23]2[C:4](=[CH:5][C:6]3[S:12](=[O:13])[C:11]4[CH:14]=[C:15]([C:18]([OH:20])=[O:19])[CH:16]=[CH:17][C:10]=4[CH2:9][CH2:8][C:7]=3[CH:22]=2)[CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 13746693HCID 13746693, compound

Product 1

HCID 13746694HCID 13746694, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Methyl 2,3,10,11-tetrahydro-1H-benzo[b]indeno[5,6-f]thiepin-7-carboxylate 5-oxide (2.00 g; 6.13 mmole) was added to a solution of 85% potassium hydroxide (808 mg; 12.26 mmole) in a mixture of water (8 ml) and ethanol (40 ml) at room temperature. After 1 hour, the solution was filtered, evaporated to 15 ml and acidified to pH 2 with hydrochloric acid. The product was collected, washed with water and dried (finally at 105° C./0.005 Torr) to yield 1.55 g (81%) with a m.p. 290°-294° dec.

Workup

  1. filtrationthe solution was filtered
  2. customevaporated to 15 ml
  3. customThe product was collected
  4. washwashed with water
  5. customdried (finally at 105° C./0.005 Torr)
  6. customto yield 1.55 g (81%) with a m.p. 290°-294° dec.

Sources & evidence

ORD record
ord-f02d6bff8f924ea4a15e2106d617121c
Source dataset
uspto-grants-1986_11
Patent number
US04622403

Reaction notes

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