Hydrochloric Acid → HCID 20228202, compound

HRID 1731636Notes

Reaction equation

HRID 1731636 reaction equation
[O:1]=[C:2]1[C:15]2[C:14]3[S:13][C:12]4=[CH:16][CH2:17][CH2:18][CH:19]=[C:11]4[CH:10]=[C:9]([C:20]([O:22]C)=[O:21])[C:8]=3[CH:7]=[CH:6][C:5]=2[CH2:4][CH2:3]1.[OH-].[K+].Cl>O>[O:1]=[C:2]1[C:15]2[C:14]3[S:13][C:12]4=[CH:16][CH2:17][CH2:18][CH:19]=[C:11]4[CH:10]=[C:9]([C:20]([OH:22])=[O:21])[C:8]=3[CH:7]=[CH:6][C:5]=2[CH2:4][CH2:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 20228201HCID 20228201, compound

Product 1

HCID 20228202HCID 20228202, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Methyl 1-oxo-2,3,9,10-tetrahydro-1H-benz[b]indeno[5,4-f]thiepin-6-carboxylate (160 mg, 0.5 mmole) was added to 4.1 ml of the potassium hydroxide solution described above and the mixture was stirred at room temperature under argon for 8 hours. Water (2 ml) was added and then 10% hydrochloric acid (0.3 ml) was added to precipitate the title compound 126 mg (81%), m.p. 298°-302° (dec.).

Workup

  1. customto precipitate the title compound 126 mg (81%), m.p. 298°-302° (dec.)

Sources & evidence

ORD record
ord-eda3b558c9ea4f43b4b6640ffb334af1
Source dataset
uspto-grants-1986_11
Patent number
US04622403

Reaction notes

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