Ammonia → Phenylephrine

Participants

Reaction Steps

Phenylephrine HCl (0.3 g, 1.47 mmole) was dissolved in 3 ml of water in a test tube to which was added 1 ml of ammonia T.S. The interior of the test tube was rubbed with a glass rod to initiate the precipitation of the free base. The phenylephrine was separated by filtration and washed with about 1 ml of ice-cold water and finally dried over silica gel for 16 hours. IR (KBr) measurements were made to confirm the preparation of the phenylephrine base.

Provenance & Evidence