Ammonia → Phenylephrine

HRID 1731783Notes

Reaction equation

HRID 1731783 reaction equation
[CH3:1][NH:2][CH2:3][C@H:4]([OH:12])[C:5]1[CH:6]=[CH:7][CH:8]=[C:9]([OH:11])[CH:10]=1.Cl.N>O>[CH3:1][NH:2][CH2:3][C@H:4]([OH:12])[C:5]1[CH:6]=[CH:7][CH:8]=[C:9]([OH:11])[CH:10]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 5284443(-)-Phenylephrine hydrochloride

Product 1

HCID 6041Phenylephrine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Phenylephrine HCl (0.3 g, 1.47 mmole) was dissolved in 3 ml of water in a test tube to which was added 1 ml of ammonia T.S. The interior of the test tube was rubbed with a glass rod to initiate the precipitation of the free base. The phenylephrine was separated by filtration and washed with about 1 ml of ice-cold water and finally dried over silica gel for 16 hours. IR (KBr) measurements were made to confirm the preparation of the phenylephrine base.

Workup

  1. customthe precipitation of the free base
  2. customThe phenylephrine was separated by filtration
  3. washwashed with about 1 ml of ice-cold water
  4. customfinally dried over silica gel for 16 hours
  5. customthe preparation of the phenylephrine base

Sources & evidence

ORD record
ord-359457253bb14a198d7ef9a7d435f8b4
Source dataset
uspto-grants-1986_11
Patent number
US04623664

Reaction notes

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