Ammonium Hydroxide → 4-Butylbenzamide

HRID 1731849Notes

Reaction equation

HRID 1731849 reaction equation
[CH2:1]([C:5]1[CH:13]=[CH:12][C:8]([C:9](Cl)=[O:10])=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].[OH-].[NH4+:15]>>[CH2:1]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([NH2:15])=[O:10])=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 1200494-Butylbenzoyl chloride

Product 1

HCID 28014584-ButylbenzamideYield 99%

Procedure

To a stirred solution of 200 ml of aqueous ammonium hydroxide was added dropwise 35 ml of 4-butylbenzoyl chloride. The resulting mixture was stirred at room temperature for several hours. The white solid was collected by filtration, washed with water, then hexane, and dried in vacuo at 60° C. to give 33.4 g (99% yield) of the desired product, mp 135°-136° C.

Workup

  1. filtrationThe white solid was collected by filtration
  2. washwashed with water
  3. dry with materialhexane, and dried in vacuo at 60° C.

Sources & evidence

ORD record
ord-ef8dd1ce5f6443e29e0a785ab3ac27b6
Source dataset
uspto-grants-1986_11
Patent number
US04623662

Reaction notes

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