Hydrochloric Acid → HCID 178487304, compound

HRID 1731917Notes

Reaction equation

HRID 1731917 reaction equation
C[O:2][C:3]1[C:4]2[N:5]([CH:15]=[N:16][N:17]=2)[C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([O:13][CH3:14])=[CH:8][CH:7]=2.Cl>C(O)(=O)C>[OH:2][C:3]1[C:4]2[N:5]([CH:15]=[N:16][N:17]=2)[C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([O:13][CH3:14])=[CH:8][CH:7]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 133856924,7-Dimethoxy-[1,2,4]triazolo[4,3-a]quinoxaline

Product 1

HCID 178487304HCID 178487304, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture consisting of 1.6 g. (0.0069 mole) of 4,7-dimethoxy-[1,2,4]triazolo[4,3-a]quinoxaline, 16 ml. of 1N hydrochloric acid and 48 ml. of glacial acetic acid was refluxed for a period of three hours. Upon completion of this step, the reaction mixture was poured over ice and filtered. The recovered product was then collected on the filter funnel and washed with diethyl ether to ultimately afford 1.19 g. (80%) of pure 4-hydroxy-7-methoxy[1,2,4]triazolo[4,3-a]quinoxaline, m.p. >250° C.

Workup

  1. additionUpon completion of this step, the reaction mixture was poured over ice
  2. filtrationfiltered
  3. customThe recovered product was then collected on the filter funnel
  4. washwashed with diethyl ether to ultimately afford 1.19 g

Sources & evidence

ORD record
ord-e160ce800f004eeebc04a0da2f78ff2e
Source dataset
uspto-grants-1986_11
Patent number
US04623725

Reaction notes

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