反应详情

A solution of 2-fluoro-4-chloro-5-hydroxyphenylhydrazine (8 g) and 2-ethoxycarbonylcyclohexanone (8 g) in acetic acid (30 ml) was heated under reflux for 4 hours. After cooling, the precipitated crystals were collected by filtration and washed with ether to give 11 g of 2-(4-chloro-2-fluoro-5-hydroxyphenyl)-2,3a,4,5,6,7-hexahydroindazol-3-one. m.p. 273°-275° C. (decomp.).

1. temperatureunder reflux for 4 hours
2. temperatureAfter cooling
3. filtrationthe precipitated crystals were collected by filtration
4. washwashed with ether