HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-oxocyclohexanecarboxylate → 2-(4-Chloro-2-fluoro-5-hydroxyphenyl)-2,3a,4,5,6,7-hexahydro-3H-indazol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-oxocyclohexanecarboxylate | HCID 95543 | — |
| Reactant | 2-Chloro-4-fluoro-5-hydrazinylphenol | HCID 185081 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-(4-Chloro-2-fluoro-5-hydroxyphenyl)-2,3a,4,5,6,7-hexahydro-3H-indazol-3-one | HCID 13753059 | 85.9% |
Reaction Steps
A solution of 2-fluoro-4-chloro-5-hydroxyphenylhydrazine (8 g) and 2-ethoxycarbonylcyclohexanone (8 g) in acetic acid (30 ml) was heated under reflux for 4 hours. After cooling, the precipitated crystals were collected by filtration and washed with ether to give 11 g of 2-(4-chloro-2-fluoro-5-hydroxyphenyl)-2,3a,4,5,6,7-hexahydroindazol-3-one. m.p. 273°-275° C. (decomp.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04624699 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-30b17604aa2447cba81c12d3369363fb |
| Source note | uspto-grants-1986_11 |