HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl isothiocyanate → 2-Amino-5-(methyl-thiocarbamoyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | 4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridin-2-amine | HCID 13519687 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Amino-5-(methyl-thiocarbamoyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine | HCID 13519688 | 55% |
Reaction Steps
1.55 G (10 mmol) of 2-amino-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine was dissolved in 25 ml of dimethylformamide and the solution was cooled in an ice-water bath. 0.88 g (12 mmol) of methyl isothiocyanate was then added. After 71/2 hours the solvent was removed by evaporation and the residue (about 2.2 g) was crystallized from acetonitrile. 1.25 g (55% yield) of the pure title compound (m.p. 188°-190° C. with decomposition) were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04624956 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-f32c17a8c4d746dab4300c85204a2adb |
| Source note | uspto-grants-1986_11 |