反应详情

1.55 G (10 mmol) of 2-amino-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine was dissolved in 25 ml of dimethylformamide and the solution was cooled in an ice-water bath. 0.88 g (12 mmol) of methyl isothiocyanate was then added. After 71/2 hours the solvent was removed by evaporation and the residue (about 2.2 g) was crystallized from acetonitrile. 1.25 g (55% yield) of the pure title compound (m.p. 188°-190° C. with decomposition) were obtained.

1. temperaturethe solution was cooled in an ice-water bath
2. customAfter 71/2 hours the solvent was removed by evaporation
3. customthe residue (about 2.2 g) was crystallized from acetonitrile