ethyl 1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate → HCID 135741244, compound

HRID 1732088Notes

Reaction equation

HRID 1732088 reaction equation
C([O:3][C:4]([CH:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]1=O)=O)C.C(=O)(O)O.[NH2:21][C:22]([NH2:24])=[NH:23]>C1(C)C(C)=CC=CC=1>[NH2:23][C:22]1[NH:24][C:4](=[O:3])[C:6]2[CH2:15][CH2:14][C:13]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[C:7]=2[N:21]=1

Participants

4

Reactant 2

HCID 251472ethyl 1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylateHCID 286947Carbonic acid-guanidine (1:1)

Product 1

HCID 135741244HCID 135741244, compoundYield 37.8%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A mixture of 2-ethoxycarbonyl-1-tetralone (0.65 g) and guanidine carbonate (0.65 g) in xylene (15 ml) was refluxed overnight and, after cooling to room temperature, the tan solid was collected by filtration, washed with water and alcohol, and then dried to yield 0.24 g of tan solid, m.p.>300° C. The solid was dissolved in Con.-HCl, concentrated in vacuo to dryness, and recrystallized from ethanol to yield a colorless solid product, (0.28 g).

Workup

  1. temperaturewas refluxed overnight
  2. filtrationthe tan solid was collected by filtration
  3. washwashed with water and alcohol
  4. customdried

Sources & evidence

ORD record
ord-acac417aa3ef4ac2ba44bf2125459b31
Source dataset
uspto-grants-1986_11
Patent number
US04625026

Reaction notes

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