Hydrochloric Acid → 2-nitromethylenetetrahydro-2H-1,3-thiazine

Temperature

0 °C

Into 50 ml of methanol were added 8.1 g of 1-amino-3-propanethiol and 5.0 g of caustic soda, followed by stirring, to be completely dissolved therein. Then, the mixture was cooled to 0° C. While stirring the solution, a solution of 5.4 g of 2,2,2-trichloro-1-nitroethane diluted in 20 ml of methanol was added dropwise slowly over 15 minutes, and the reaction was carried out for one hour. The reaction was exothermic and the liquid temperature was maintained at lower than 10° C. (about 8° C.). After the reaction, the reaction mixture was neutralized to pH 7 with 6 N aqueous hydrochloric acid, and then with addition of 50 ml of water, extraction with 100 ml of dichloromethane was repeated four times. The extracts were concentrated to give 2.91 g of tetrahydro-2-(nitromethylene)-1,3-thiazine (yield: 60.1%).

1. dissolutionto be completely dissolved
2. stirringWhile stirring the solution
3. additionwas added dropwise slowly over 15 minutes
4. temperaturethe liquid temperature was maintained at lower than 10° C. (about 8° C.)
5. customAfter the reaction
6. concentrationThe extracts were concentrated

ORD record

ord-7509df51d9f84eb183480331780f4936

Source dataset

uspto-grants-1986_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04625025