Aniline → HCID 13723408, compound

HRID 1732116Notes

Reaction equation

HRID 1732116 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([NH:10][C:11]2[O:12][CH2:13][C:14](=O)[C:15]=2[C:16]([OH:18])=[O:17])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].C1N(P(Cl)(N2C(=O)OCC2)=O)C(=O)OC1.[NH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>C(Cl)Cl>[N+:1]([C:4]1[CH:5]=[C:6]([NH:10][C:11]([C:15]2[C:16](=[O:18])[O:17][CH2:13][C:14]=2[NH:35][C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)=[O:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

5

Reactant 3

HCID 6115AnilineHCID 152842Bis(2-oxo-3-oxazolidinyl)phosphinic chlorideHCID 13723399HCID 13723399, compound

Product 1

HCID 13723408HCID 13723408, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title derivative was prepared by a procedure similar to that described in Example 8 starting with 2-[(m-nitrophenyl)amino]-4-oxo-3-furoic acid (7.4 grams, 0.028 mol), BOP-Cl (7.13 grams, 0.028 mol) and aniline (2.58 ml, 0.025 mol) dissolved in 90 ml methylene chloride. Yield: 6.71 g, mp 194°-195° C. (R2 =C6H4NO2 --m).

Workup

  1. customThe title derivative was prepared by a procedure similar to

Sources & evidence

ORD record
ord-d2941e58985f489c9930b25946197714
Source dataset
uspto-grants-1986_11
Patent number
US04625040

Reaction notes

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