Formaldehyde → HCID 12773702, compound

HRID 1732142Notes

Reaction equation

HRID 1732142 reaction equation
[ClH:1].[NH2:2][CH2:3][CH:4]([C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[NH:11][CH:10]=1)[C:5]([O:7][CH3:8])=[O:6].C=O.[CH3:20]COCC>CO>[ClH:1].[CH2:20]1[C:10]2[NH:11][C:12]3[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:9]=2[CH:4]([C:5]([O:7][CH3:8])=[O:6])[CH2:3][NH:2]1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 3283Diethyl EtherHCID 11470823HCID 11470823, compound

Product 1

HCID 12773702HCID 12773702, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.04 g of methyl 3-amino-2-(indol-3-yl)propionate hydrochloride are dissolved in 60 ml of methanol. 0.83 g of 35% formalin is added thereto, and the mixture is stirred at room temperature for 18 hours. After the reaction, ether is added to the mixture and crystalline precipitates are collected by filtration and dried, whereby 2.04 g of methyl (4RS)-1,2,3,4-tetrahydro-β-carboline-4-carboxylate hydrochloride are obtained as colorless needles. Yield: 95%

Workup

  1. additionis added to the mixture
  2. customcrystalline precipitates
  3. filtrationare collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-c867e6fff0ba44ccae82c41d32bb22b2
Source dataset
uspto-grants-1986_11
Patent number
US04625032

Reaction notes

Loading…