Formaldehyde → HCID 12773702, compound

Participants

Reaction Steps

2.04 g of methyl 3-amino-2-(indol-3-yl)propionate hydrochloride are dissolved in 60 ml of methanol. 0.83 g of 35% formalin is added thereto, and the mixture is stirred at room temperature for 18 hours. After the reaction, ether is added to the mixture and crystalline precipitates are collected by filtration and dried, whereby 2.04 g of methyl (4RS)-1,2,3,4-tetrahydro-β-carboline-4-carboxylate hydrochloride are obtained as colorless needles. Yield: 95%

Provenance & Evidence