反应详情

Into a 500 ml 4-neck flask, equipped with a stirrer, reflux cooler, dropping funnel and water separator, 126.5 g (1 mole) of benzylchloride, 81 g (1 mole) of 2-methyl-2-butene-nitrile, 100 ml of toluene, and 10 g of tetrabutylammonium bromide were first introduced and heated to reflux. To this mixture, 40 g (1 mole) of solid sodium hyroxide were added in portions. The reaction mixture was then maintained one more hour at reflux. Thereupon, it was washed to neutrality with water, the phases were separated and the organic phase distilled as described in Example 1. The yield in desired product was 103.5 g, corresponding to 61% of the theoretical.

1. customInto a 500 ml 4-neck flask, equipped with a stirrer
2. temperaturereflux cooler
3. temperatureheated to reflux
4. temperatureThe reaction mixture was then maintained one more hour
5. temperatureat reflux
6. washThereupon, it was washed
7. customthe phases were separated
8. distillationthe organic phase distilled