4'-Chloropropiophenone → 2-Bromo-1-(4-chlorophenyl)propan-1-one

HRID 1732148Notes

Reaction equation

HRID 1732148 reaction equation
[CH3:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=[O:4].[Br:12]Br>C(OCC)C>[Br:12][CH:2]([CH3:1])[C:3]([C:5]1[CH:6]=[CH:7][C:8]([Cl:11])=[CH:9][CH:10]=1)=[O:4]

Participants

4

Reactant 2

HCID 226974'-ChloropropiophenoneHCID 24408Bromine

Product 1

HCID 37882192-Bromo-1-(4-chlorophenyl)propan-1-one

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

4-Chloropropiophenone (33.6 g.) was dissolved in anhydrous diethyl ether (50 ml.), stirred and cooled in an ice bath while bromine (32 g.) was added dropwise over 30 minutes. The solid which formed was filtered off, washed with water and air-dried to give 2-bromo-4'-chloropropiophenone, m.p. 77°-79°.

Workup

  1. additionwas added dropwise over 30 minutes
  2. customThe solid which formed
  3. filtrationwas filtered off
  4. washwashed with water
  5. customair-dried

Sources & evidence

ORD record
ord-d0b1890de4d1444cb92880577ea74d94
Source dataset
uspto-grants-1986_11
Patent number
US04625036

Reaction notes

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