Potassium Permanganate → HCID 178519623, compound

HRID 1732149Notes

Reaction equation

HRID 1732149 reaction equation
[F:1][C:2]1[CH:13]=[CH:12][C:5]([CH2:6][C:7]2[N:11]=[CH:10][NH:9][N:8]=2)=[CH:4][CH:3]=1.[Mn]([O-])(=O)(=O)=[O:15].[K+]>O>[F:1][C:2]1[CH:13]=[CH:12][C:5]([C:6]([C:7]2[N:11]=[CH:10][NH:9][N:8]=2)=[O:15])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 516875Potassium PermanganateHCID 178505659HCID 178505659, compound

Product 1

HCID 178519623HCID 178519623, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3-(4-Fluorobenzyl)-1,2,4-triazole (9 g.) and potassium permanganate (13.5 g.) were heated in water at 80° for 1 hour. The reaction mixture was filtered, and the residue was washed twice each with water and chloroform. The combined filtrate and washings were adjusted to pH 3 and filtered. The solid residue was dissolved, as far as possible, in hot methanol, the solution was filtered and evaporated to dryness to give 3-(4-fluorobenzoyl)-1,2,4-triazole as a cream-colored solid, m.p. 225°-230°.

Workup

  1. filtrationThe reaction mixture was filtered
  2. washthe residue was washed twice each with water and chloroform
  3. filtrationfiltered
  4. dissolutionThe solid residue was dissolved
  5. filtrationas far as possible, in hot methanol, the solution was filtered
  6. customevaporated to dryness

Sources & evidence

ORD record
ord-36b2e81f32a24f069c785815762e27a7
Source dataset
uspto-grants-1986_11
Patent number
US04625036

Reaction notes

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