反应详情

A mixture of the so-prepared 6-fluorocarbostyril (2.9 gm, 0.018 mole) and 30.0 ml of phosphorous oxychloride was refluxed for 1.5 hr. Most of the excess phosphorous oxychloride was then distilled off under aspirator vacuum and the residue poured over crushed ice. The reaction mixture was made nearly neutral with 50% sodium hydroxide. The crude solid product was collected by filtration, taken up in

1. temperaturewas refluxed for 1.5 hr
2. distillationMost of the excess phosphorous oxychloride was then distilled off under aspirator vacuum
3. additionthe residue poured
4. customover crushed ice
5. filtrationThe crude solid product was collected by filtration