Ammonia → N-(3-dimethylaminopropyl)-3-methoxypropionamide

HRID 1732226Notes

Reaction equation

HRID 1732226 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][C:5]([NH2:7])=[O:6].[CH3:8][N:9]([CH3:14])[CH2:10][CH2:11][CH2:12]N.N>>[CH3:8][N:9]([CH3:14])[CH2:10][CH2:11][CH2:12][NH:7][C:5](=[O:6])[CH2:4][CH2:3][O:2][CH3:1]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 7993N,N-Dimethyl-1,3-propanediamineHCID 52524813-Methoxypropanamide

Product 1

HCID 3097421N-(3-dimethylaminopropyl)-3-methoxypropionamide

Procedure

103.1 g (1.0 mole) of 3-methoxypropionamide are heated with 107.3 g (1.05 mole) of 3-dimethylaminopropylamine for 6 hours in a temperature range of 145°-170° C. until the evolution of ammonia is complete. In the subsequent distillation in a high vacuum 176 g (0.93 mole=93.5% of the theoretical yield) of a colorless liquid are obtained having Bp0.1 of 97°-99° C.

Workup

  1. distillationIn the subsequent distillation in a high vacuum 176 g (0.93 mole=93.5% of the
  2. customtheoretical yield) of a colorless liquid
  3. customare obtained
  4. customBp0.1 of 97°-99° C.

Sources & evidence

ORD record
ord-b0e444c009db42a7915cf921cba49448
Source dataset
uspto-grants-1980_12
Patent number
US04237067

Reaction notes

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