反应详情

A solution of 2.0 g of 2-chloro-4-phenylquinoline and 2.7 g of 1-ethylpiperazine in 15 ml of toluene was heated under reflux for 10 hours. To the reaction mixture was added water and the resulting mixture was extracted with ethyl acetate. The extracts were dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was chromatographed on silica gel (25 g) using chloroform as an eluent. Fractions containing the title compound were pooled and concentrated to give the title compound (2.3 g, 87% ), m.p. 87°-88° C.

1. temperatureunder reflux for 10 hours
2. extractionthe resulting mixture was extracted with ethyl acetate
3. dry with materialThe extracts were dried over anhydrous sodium sulfate
4. concentrationconcentrated under reduced pressure
5. customThe residue was chromatographed on silica gel (25 g)
6. additionFractions containing the title compound
7. concentrationconcentrated