反应详情

A stirred suspension of 3.0 g of 4-phenyl-2-(1-piperazinyl)quinoline, 1.9 g of ethyl iodide and 1.1 g of sodium carbonate in 30 ml of methyl ethyl ketone was heated under reflux for 12 hours. The reaction mixture was concentrated under reduced pressure. To the residue was added water and the resulting mixture was extracted with ethyl acetate. The dried extracts were concentrated to give an oily residue, which was chromatographed on silica gel (30 g) using chloroform as an eluent. There was obtained the title compound (2.8 g, 85%), m.p. 87°-88° C.

1. temperaturewas heated
2. temperatureunder reflux for 12 hours
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. additionTo the residue was added water
5. extractionthe resulting mixture was extracted with ethyl acetate
6. concentrationThe dried extracts were concentrated
7. customto give an oily residue, which
8. customwas chromatographed on silica gel (30 g)