2-Aminothiazole → HCID 54410851, compound

Participants

Reaction Steps

5 g of 2-aminothiazole are dissolved in 50 ml of ethanol and 8.5 g of acetylene dicarboxylic acid diethyl ester are added to the resulting solution. The mixture increases in temperature and a solid substance begins to precipitate. After standing overnight, it is filtered off, washed with a little ethanol and dried. 7H-thiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylic acid ethyl ester melting at 173° to 175° C. is thus obtained in a yield of 8.2 g (85.4% of the theoretical).

Provenance & Evidence