2-Aminothiazole → HCID 54410851, compound

HRID 1732303Notes

Reaction equation

HRID 1732303 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[CH2:7]([O:9][C:10]([C:12]#[C:13][C:14](OCC)=[O:15])=[O:11])[CH3:8]>C(O)C>[CH2:7]([O:9][C:10]([C:12]1[N:6]2[CH:5]=[CH:4][S:3][C:2]2=[N:1][C:14](=[O:15])[CH:13]=1)=[O:11])[CH3:8]

Participants

4

Reactant 2

HCID 21552-AminothiazoleHCID 69803Diethyl acetylenedicarboxylate

Product 1

HCID 54410851HCID 54410851, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5 g of 2-aminothiazole are dissolved in 50 ml of ethanol and 8.5 g of acetylene dicarboxylic acid diethyl ester are added to the resulting solution. The mixture increases in temperature and a solid substance begins to precipitate. After standing overnight, it is filtered off, washed with a little ethanol and dried. 7H-thiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylic acid ethyl ester melting at 173° to 175° C. is thus obtained in a yield of 8.2 g (85.4% of the theoretical).

Workup

  1. temperatureThe mixture increases in temperature
  2. customto precipitate
  3. filtrationit is filtered off
  4. washwashed with a little ethanol
  5. customdried

Sources & evidence

ORD record
ord-9812ae515cf040e09f276479069daa5c
Source dataset
uspto-grants-1980_12
Patent number
US04237136

Reaction notes

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