反应详情

Dissolve 2 gm. of 3-hydroxymethyl-10,11-dihydrodibenzo[b,f]thiepin in 200 ml. of methylene chloride at room temperature. Add 1.7 gm. of m-chloroperbenzoic acid. Stir at room temperature for 2 hours. Add 4 gm. of calcium hydroxide and 50 ml. of methylene chloride. Continue stirring for 15 minutes. Filter through celite and evaporate the filtrate to dryness. Crystallize the residue from toluene to obtain the title product (m.p., 144°-146° C.).

1. dissolutionDissolve 2 gm
2. customat room temperature
3. additionAdd 1.7 gm
4. additionAdd 4 gm
5. stirringContinue stirring for 15 minutes
6. filtrationFilter through celite
7. customevaporate the filtrate to dryness
8. customCrystallize the residue from toluene