Isobutyraldehyde → HCID 70543438, compound

HRID 1732406Notes

Reaction equation

HRID 1732406 reaction equation
[NH2:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1.[CH:9](=O)[CH:10]([CH3:12])[CH3:11]>>[CH:9](=[C:8]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]1[CH2:2][NH2:1])[CH:10]([CH3:12])[CH3:11]

Participants

3

Reactant 2

HCID 6561IsobutyraldehydeHCID 195092-Pyridinemethanamine

Product 1

HCID 70543438HCID 70543438, compoundYield 85.5%

Procedure

The procedure is carried out as described in Example 1(a) but with the use of 216 g (2 mols) of 2-aminomethylpyridine and 144 g (2 mols) isobutyraldehyde. After a reaction time of 2 hours at 35°-40° C., subsequent distillation leaves 277 g (1.71 mols) of isobutylidene-2-aminomethylpyridine; yield 85.5% of theory; b.p. 69° C./200 Pa.

Workup

  1. distillationAfter a reaction time of 2 hours at 35°-40° C., subsequent distillation

Sources & evidence

ORD record
ord-ff3ebe4c315242f9ad531bca9eaec962
Source dataset
uspto-grants-1980_12
Patent number
US04237275

Reaction notes

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