反应详情

温度

18 °C

A 150 mg quantity of 3-methoxycarbonylmethyl-2-(cis-2-pentenyl)-cyclopentanol is dissolved in 10 ml of methylene chloride. A 2 ml quantity of chromic acid solution of 2 M concentration is added dropwise to the solution. The mixture is stirred at about 18° C. for 12 hours and thereafter extracted with ethyl acetate. The extract is washed with aqueous solution of sodium chloride, dried and concentrated. The residue is purified with a silica gel column and distilled in a vacuum, affording 3-methoxycarbonylmethyl-2-(cis-2-pentenyl)-cyclopentanone (compound (4), R2 =CH3) in a yield of 88%, b.p. 92°-96° C./2.7 mm Hg.

1. concentrationA 2 ml quantity of chromic acid solution of 2 M concentration
2. additionis added dropwise to the solution
3. extractionextracted with ethyl acetate
4. washThe extract is washed with aqueous solution of sodium chloride
5. customdried
6. concentrationconcentrated
7. customThe residue is purified with a silica gel column
8. distillationdistilled in a vacuum