Water → Ethyl 2-(4-phthalimidobutyl)benzofuran-6-carboxylate

HRID 1732575Notes

Reaction equation

HRID 1732575 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[O:7][C:8]2[CH:14]=[C:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:12]=[CH:11][C:9]=2[CH:10]=1.[C:20]1(=[O:30])[NH:24][C:23](=[O:25])[C:22]2=[CH:26][CH:27]=[CH:28][CH:29]=[C:21]12.[K].O>CN(C)C=O>[C:20]1(=[O:30])[N:24]([CH2:2][CH2:3][CH2:4][CH2:5][C:6]2[O:7][C:8]3[CH:14]=[C:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:12]=[CH:11][C:9]=3[CH:10]=2)[C:23](=[O:25])[C:22]2=[CH:26][CH:27]=[CH:28][CH:29]=[C:21]12

Participants

5

Reactant 3

HCID 962WaterHCID 20303934Ethyl 2-(4-bromobutyl)benzofuran-6-carboxylateHCID 24194345Phthalimide potassium salt

Product 1

HCID 20303948Ethyl 2-(4-phthalimidobutyl)benzofuran-6-carboxylate

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of ethyl 2-(4-bromobutyl)benzofuran-6-carboxylate (3.25 g., 0.01 mole) and potassium phthalimide (2.04 g., 0.011 mole) in dimethylformamide (25 ml.) is stirred at 25°-27° C. for 18 hours. The solution is poured into water. The precipitated ethyl 2-(4-phthalimidobutyl)benzofuran-6-carboxylate is collected by filtration.

Workup

  1. filtrationThe precipitated ethyl 2-(4-phthalimidobutyl)benzofuran-6-carboxylate is collected by filtration

Sources & evidence

ORD record
ord-51822b768ea14fcfbe7c66b93e6e7b8c
Source dataset
uspto-grants-1980_12
Patent number
US04238487

Reaction notes

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