反应详情

A solution of ethyl 2-(4-phthalimidobutyl)-benzofuran-6-carboxylate (3.9 g., 0.01 mole) and hydrazine hydrate (0.55 g., 0.011 mole) in ethanol (20 ml.) is heated at 60° C. for 8 hours. The solvent is evaporated at reduced pressure. The solid residue is treated with water and 5 N sodium hydroxide solution and then is extracted with chloroform. The evaporation of the solvent from the organic extract provides ethyl 2-(4-aminobutyl)benzofuran-6-carboxylate.

1. customThe solvent is evaporated at reduced pressure
2. additionThe solid residue is treated with water and 5 N sodium hydroxide solution
3. extractionis extracted with chloroform
4. customThe evaporation of the solvent from the
5. extractionorganic extract