Hydrochloric Acid → HCID 20303926, compound

HRID 1732593Notes

Reaction equation

HRID 1732593 reaction equation
[C:1]([N:4]1[C:12]2[C:11]([Cl:13])=[CH:10][CH:9]=[C:8]3[C:14](=[O:20])[CH:15]([N:17]=[N+]=[N-])[CH2:16][C:6]([C:7]=23)=[CH:5]1)(=[O:3])[CH3:2].Cl>C(OC(=O)C)C.C(O)C>[ClH:13].[C:1]([N:4]1[C:12]2[C:11]([Cl:13])=[CH:10][CH:9]=[C:8]3[C:14](=[O:20])[CH:15]([NH2:17])[CH2:16][C:6]([C:7]=23)=[CH:5]1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20303922HCID 20303922, compound

Product 1

HCID 20303926HCID 20303926, compound

Reagents, catalysts & solvents 1

HCID 21584252Ethanol ethylacetateSolvent

Procedure

Into a stirred solution of 1-acetyl-4-azido-8-chloro-3,4-dihydrobenz[cd]-indol-5(1H)-one (3.5 g., 0.012 mole) in ethylacetate-ethanol (1:1) (200 ml.), containing 4 gm. of 6 N hydrochloric acid and 0.5 g. of 10% palladium on carbon catalyst, is bubbled a stream of hydrogen gas. After 2.5 hours the product which has separated is recovered by filtration. The yield of crude product which contains some of the catalyst is 2.6 g. (72%).

Workup

  1. customof 10% palladium on carbon catalyst, is bubbled a stream of hydrogen gas
  2. customAfter 2.5 hours the product which has separated
  3. filtrationis recovered by filtration

Sources & evidence

ORD record
ord-0d575e784637469ca212fc6144b294a2
Source dataset
uspto-grants-1980_12
Patent number
US04238486

Reaction notes

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