6-Phenoxy-2-pyridinemethanol → HCID 70591462, compound

HRID 1732706Notes

Reaction equation

HRID 1732706 reaction equation
[O:1]([C:8]1[N:13]=[C:12]([CH2:14][OH:15])[CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:16][Mg]Br>C1COCC1>[CH3:16][C:12]1([CH2:14][OH:15])[CH:11]=[CH:10][CH:9]=[C:8]([O:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[NH:13]1

Participants

4

Reactant 2

HCID 128791556-Phenoxy-2-pyridinemethanolHCID 178418573HCID 178418573, compound

Product 1

HCID 70591462HCID 70591462, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The alcohol, 2-methyl(6-phenoxy-2-pyridyl) methanol is prepared by oxidation of (6-phenoxy-2-pyridyl) methanol using chromuim trioxide-pyridine to the aldehyde, 6-phenoxypyridyl-2-carboxaldehyde, which by grignard reaction using methyl magnesium bromide in THF provides the desired alcohol.

Sources & evidence

ORD record
ord-c94cd8b28e4e4c82ab32168c4b1c340d
Source dataset
uspto-grants-1980_12
Patent number
US04238614

Reaction notes

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