Hydrochloric Acid → 4-Bromo-1-chloro-2-fluorobenzene

2-Chloro-5-bromoaniline (258 g) is added to concentrated hydrochloric acid (750 ml) and the mixture is stirred at 80°-90° C. until formation of a homogeneous suspension. Then, it is cooled and diazotized at 0°-5° C. by dropwise addition of sodium nitrite (95.1 g) in water (330 ml) during 1 hour. The mixture is stirred for an additional 20 minutes and then a solution of fluoroboric acid (700 ml) (prepared by dissolving 264 g of boric acid in 744 ml of 40% hydrofluoric acid) is added. After 30 minutes of stirring, the separated fluoroborate was filtered, washed successively with a small amount of a fluoroboric acid solution, ethanol and ether, and dried thoroughly in air and in vacuo. The thermal decomposition of the fluoroborate is carried out in two portions. Each portion is heated in a flask with a direct flame, the internal temperature during the decomposition being 130°-170° C. The distillates are combined and shaken with water (250 ml) and ether (250 ml). The ethereal layer is washed with 10% sodium hydroxide solution, 3 N-HCl and water and dried over sodium sulfate. The ether is evaporated and the residue is distilled, yielding 184.2 g (70%) of 2-chloro-5-bromofluorobenzene, b.p. 130°-142° C./20 Torr.

1. temperatureThen, it is cooled
2. stirringThe mixture is stirred for an additional 20 minutes
3. stirringAfter 30 minutes of stirring
4. filtrationthe separated fluoroborate was filtered
5. washwashed successively with a small amount of a fluoroboric acid solution, ethanol and ether
6. customdried thoroughly in air and in vacuo
7. temperatureEach portion is heated in a flask with a direct flame
8. custombeing 130°-170° C
9. stirringshaken with water (250 ml) and ether (250 ml)
10. washThe ethereal layer is washed with 10% sodium hydroxide solution, 3 N-HCl and water
11. dry with materialdried over sodium sulfate
12. customThe ether is evaporated
13. distillationthe residue is distilled

ORD record

ord-3b7044bf15884891b5fc552337ba2bd9

Source dataset

uspto-grants-1980_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04238611