1H-1,2,4-Triazole → HCID 70586854, compound

HRID 1732814Notes

Reaction equation

HRID 1732814 reaction equation
[CH2:1]([O:5][C:6](=[O:11])/[CH:7]=[C:8](\Cl)/[CH3:9])[CH:2]([CH3:4])[CH3:3].[NH:12]1[CH:16]=[N:15][CH:14]=[N:13]1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH2:1]([O:5][C:6](=[O:11])/[CH:7]=[C:8](\[N:12]1[CH:16]=[N:15][CH:14]=[N:13]1)/[CH3:9])[CH:2]([CH3:4])[CH3:3]

Participants

5

Reactant 3

HCID 92571H-1,2,4-TriazoleHCID 11430Potassium CarbonateHCID 86737388HCID 86737388, compound

Product 1

HCID 70586854HCID 70586854, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

0.1 Mol (17.7 g) of 3-chlorocrotonic acid isobutyl ester in 100 ml acetonitrile, 012 mol (8.3 g) of 1,2,4-triazole and 0.12 mol (16.5 g) of anhydrous potassium carbonate were refluxed for 5 hours. After removal of the solvent under reduced presure, the reaction mixture was cooled, water was added and the resulting mixture was extracted with methylene chloride. After distillation of the methylene chloride under reduced pressure, the 3-(1,2,4-triazol-1-yl)-crotonic acid isobutyl ester was obtained in the form of a weakly yellow oil.

Workup

  1. customAfter removal of the solvent under reduced presure
  2. temperaturethe reaction mixture was cooled
  3. additionwater was added
  4. extractionthe resulting mixture was extracted with methylene chloride
  5. distillationAfter distillation of the methylene chloride under reduced pressure

Sources & evidence

ORD record
ord-6b1e4c99ac4b4b018b173940458da792
Source dataset
uspto-grants-1980_12
Patent number
US04239525

Reaction notes

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