Propionic Acid → (1-Aminoethylidene)bisphosphonic acid

HRID 1732835Notes

Reaction equation

HRID 1732835 reaction equation
[P:1]([OH:4])([OH:3])[OH:2].C(O)(=O)CC.[C:10](#[N:12])[CH3:11]>>[NH2:12][C:10]([P:1]([OH:4])(=[O:2])[OH:3])([P:1]([OH:4])(=[O:3])[OH:2])[CH3:11]

Participants

4

Reactant 3

HCID 1032Propionic AcidHCID 6342AcetonitrileHCID 107909Phosphorous acid

Product 1

HCID 84770(1-Aminoethylidene)bisphosphonic acidYield 85%

Procedure

Into a reactor similar to the above were charged 174 g phosphorous acid and 92 g propionic acid. 41.5 g acetonitrile was introduced slowly for 72 minutes at 135°-140° C. into the agitated mixture which was maintained for an additional 10 hours at that temperature. The 1-aminoethane-1, 1-diphosphonic acid produced was isolated from the reaction mixture in the same manner as described in Example 1. The yield was 85% of the theory calculated on the acetonitrile employed.

Workup

  1. temperaturewas maintained for an additional 10 hours at that temperature

Sources & evidence

ORD record
ord-053a5d90259a423394e4d6c86701c574
Source dataset
uspto-grants-1980_12
Patent number
US04239695

Reaction notes

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