Propionic Acid → (1-Aminoethylidene)bisphosphonic acid

Participants

Reaction Steps

Into a reactor similar to the above were charged 174 g phosphorous acid and 92 g propionic acid. 41.5 g acetonitrile was introduced slowly for 72 minutes at 135°-140° C. into the agitated mixture which was maintained for an additional 10 hours at that temperature. The 1-aminoethane-1, 1-diphosphonic acid produced was isolated from the reaction mixture in the same manner as described in Example 1. The yield was 85% of the theory calculated on the acetonitrile employed.

Provenance & Evidence