Propionitrile → 15049-86-2

HRID 1732837Notes

Reaction equation

[P:1]([OH:4])([OH:3])[OH:2].[C:5](#[N:8])[CH2:6][CH3:7]>>[NH2:8][C:5]([P:1]([OH:4])(=[O:2])[OH:3])([P:1]([OH:4])(=[O:3])[OH:2])[CH2:6][CH3:7]

Participants

Reactant 2

HCID 7854Propionitrile

HCID 107909Phosphorous acid2×

Product 1

HCID 436880715049-86-2Yield 71%

Procedure

Into a reactor like the above was charged 261 g phosphorous acid. 44.3 g propionitrile was introduced slowly for 70 minutes at 135°-143° C. into the agitated phosphorous acid. The reactant mixture was held for additional 10 hours at 150°-155° C. The 1-aminopropane-1, 1-diphosphonic acid produced was isolated from the reaction mixture in the manner described in Example 1.

Sources & evidence

ORD record: ord-6dc0657f27f741b38a5a85e088635bd7
Source dataset: uspto-grants-1980_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04239695

Reaction notes

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