Hydrochloric Acid → HCID 86737393, compound

Participants

Reaction Steps

When the hydrochloride (XI) in water is stirred with acetic anhydride and sodium acetate trihydrate is added, the product is collected and recrystallized from acetone-hexane to provide N-ethyl-6'-[4-(hydroxymethyl)-3-thienyloxy]-m-acetotoluidide (XII). When 4-(2-amino-p-tolyloxy)-3-thiophenecarboxylic acid (IX) and lithium aluminum hydride in ether is refluxed for 16 hours and the product is treated with alcoholic hydrochloric acid, 4-(2-amino-p-tolyloxy)-3-thiophenemethanol hydrochloride (XIII) is obtained.

Provenance & Evidence