Hydrochloric Acid → HCID 86737393, compound

HRID 1732928Notes

Reaction equation

HRID 1732928 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[C:10]([C:14](O)=[O:15])=[CH:11][S:12][CH:13]=2)[CH:5]=[CH:4][C:3]=1[CH3:17].[H-].[Al+3].[Li+].[H-].[H-].[H-].[ClH:24]>CCOCC>[ClH:24].[NH2:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[C:10]([CH2:14][OH:15])=[CH:11][S:12][CH:13]=2)[CH:5]=[CH:4][C:3]=1[CH3:17]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 21226445Aluminium lithium hydrideHCID 70590282HCID 70590282, compound

Product 1

HCID 86737393HCID 86737393, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

When the hydrochloride (XI) in water is stirred with acetic anhydride and sodium acetate trihydrate is added, the product is collected and recrystallized from acetone-hexane to provide N-ethyl-6'-[4-(hydroxymethyl)-3-thienyloxy]-m-acetotoluidide (XII). When 4-(2-amino-p-tolyloxy)-3-thiophenecarboxylic acid (IX) and lithium aluminum hydride in ether is refluxed for 16 hours and the product is treated with alcoholic hydrochloric acid, 4-(2-amino-p-tolyloxy)-3-thiophenemethanol hydrochloride (XIII) is obtained.

Sources & evidence

ORD record
ord-1ab04983abd74647a77bd854d30d65b8
Source dataset
uspto-grants-1980_12
Patent number
US04239898

Reaction notes

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