Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Chloroacetophenone | HCID 10757 | — |
| Reactant | Methyl 3-mercaptopropionate | HCID 18050 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 43218479 | HCID 43218479 | 90% |
Reaction Steps
15.5 Parts of chloroacetophenone are added to a solution, cooled to 0° C., of 12 parts of 3-mercapto-propionic acid methyl ester and 15.3 parts by volume of triethylamine in 100 parts by volume of chloroform. The mixture is stirred for 2 hours at 0° C. and is washed with water, and the organic phase is separated off, dried and concentrated. 21 parts (90% of theory) of 3-(benzoylmethylthio)-propionoic acid methyl ester of boiling point 156°-160° C./0.3 mbar are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04239897 |
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| Source dataset | uspto-grants-1980_12 |
|---|
| ORD ID | ord-2d2fa5d50fd8480caae8374b9210678a |
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| Source note | uspto-grants-1980_12 |
|---|
