Triethylamine → HCID 43218479, compound

HRID 1732944Notes

Reaction equation

HRID 1732944 reaction equation
Cl[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4].[CH3:11][O:12][C:13](=[O:17])[CH2:14][CH2:15][SH:16].C(N(CC)CC)C>C(Cl)(Cl)Cl>[CH3:11][O:12][C:13](=[O:17])[CH2:14][CH2:15][S:16][CH2:2][C:3](=[O:4])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 107572-ChloroacetophenoneHCID 18050Methyl 3-mercaptopropionate

Product 1

HCID 43218479HCID 43218479, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
0 °C

Procedure

15.5 Parts of chloroacetophenone are added to a solution, cooled to 0° C., of 12 parts of 3-mercapto-propionic acid methyl ester and 15.3 parts by volume of triethylamine in 100 parts by volume of chloroform. The mixture is stirred for 2 hours at 0° C. and is washed with water, and the organic phase is separated off, dried and concentrated. 21 parts (90% of theory) of 3-(benzoylmethylthio)-propionoic acid methyl ester of boiling point 156°-160° C./0.3 mbar are obtained.

Workup

  1. washis washed with water
  2. customthe organic phase is separated off
  3. customdried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-2d2fa5d50fd8480caae8374b9210678a
Source dataset
uspto-grants-1980_12
Patent number
US04239897

Reaction notes

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