Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Boc-Phe-ONp | HCID 111308 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 70564179 | HCID 70564179 | — |
Reaction Steps
250 ml of 5 N ethereal hydrogen chloride were added to a solution of 21 g of tert.-butoxycarbonyl-L-phenylalanine p-nitrophenyl ester in 50 ml of anhydrous tetrahydrofurane and the reaction mixture was stirred for 1 hour at 22° C., with exclusion of moisture. 250 ml of absolute ether were added to the precipitate formed and the yellowish crystals were isolated by filtration; 15.9 g (99% of theory) of melting point 191°-193° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04239902 |
|---|
| Source dataset | uspto-grants-1980_12 |
|---|
| ORD ID | ord-0ebfadd172fd4bf28d782ee338523eea |
|---|
| Source note | uspto-grants-1980_12 |
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