Hydrochloric Acid → HCID 70564179, compound
Reaction equation
[ClH:1].[N+:2]([C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12](=[O:29])[C@H:13]([CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[NH:14]C(OC(C)(C)C)=O)=[CH:7][CH:6]=1)([O-:4])=[O:3].CCOCC>O1CCCC1>[ClH:1].[N+:2]([C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12](=[O:29])[C@H:13]([CH2:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[NH2:14])=[CH:7][CH:6]=1)([O-:4])=[O:3]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 22 °C
Procedure
250 ml of 5 N ethereal hydrogen chloride were added to a solution of 21 g of tert.-butoxycarbonyl-L-phenylalanine p-nitrophenyl ester in 50 ml of anhydrous tetrahydrofurane and the reaction mixture was stirred for 1 hour at 22° C., with exclusion of moisture. 250 ml of absolute ether were added to the precipitate formed and the yellowish crystals were isolated by filtration; 15.9 g (99% of theory) of melting point 191°-193° C.
Workup
- customformed
- customthe yellowish crystals were isolated by filtration
Sources & evidence
- ORD record
- ord-0ebfadd172fd4bf28d782ee338523eea
- Source dataset
- uspto-grants-1980_12
- Patent number
- US04239902
Reaction notes
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