反应详情

To a mixture of 8.8 g of N-ethyl-6-methoxy-1,2,3,4-tetrahydro-2-naphthylamine, 6.1 g of triethylamine and 80 ml of anhydrous benzene, 7.1 g of 3-(methoxycarbonyl)-propionyl chloride dissolved in 10 ml of anhydrous benzene was added dropwise. After the resulting solution was heated for 2.5 hours at reflux, the solution was allowed to stand overnight at room temperature (about 25° C.). The reaction solution was washed with a 2N-HCl aqueous solution, water, a 2 N-NaOH aqueous solution and water in order, and dried over anhydrous sodium sulfate. Then, the solution was concentrated under reduced pressure to obtain 12.5 g of N-ethyl-N-[3-(methoxycarbonyl)propionyl]-6-methoxy-1,2,3,4-tetrahydro-2-naphthylamine as a pale-yellow oily product.

1. additionwas added dropwise
2. temperatureAfter the resulting solution was heated for 2.5 hours
3. temperatureat reflux
4. custom(about 25° C.)
5. washThe reaction solution was washed with a 2N-HCl aqueous solution, water
6. dry with materiala 2 N-NaOH aqueous solution and water in order, and dried over anhydrous sodium sulfate
7. concentrationThen, the solution was concentrated under reduced pressure