HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 2-[3-Chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 2-[3-Chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic acid tert.-butylester | HCID 57052709 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-[3-Chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic acid | HCID 20303410 | 94.7% |
Reaction Steps
341 mg (1 mmole) of 2-[3-chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic acid tert.-butylester are heated to the boil for 2 hours with 10 mg of p-toluenesulfonic acid in toluene. The reaction solution is washed with water, dried and concentrated to obtain 270 mg (94.7% of theory) of 2-[3-chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic acid (m.p. 102° to 103° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04239901 |
| Source dataset | uspto-grants-1980_12 |
| ORD ID | ord-35992fd2a0664dd28cf4b13b6e063ba8 |
| Source note | uspto-grants-1980_12 |