Sodium Bicarbonate → HCID 23716984, compound

HRID 1733013Notes

Reaction equation

HRID 1733013 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]([CH3:18])[C:15]([OH:17])=[O:16])[CH:5]=[CH:6][C:7]=1[N:8]1[CH:12]=[C:11]([Cl:13])[CH:10]=[N:9]1.C(=O)([O-])O.[Na+:23]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]([CH3:18])[C:15]([O-:17])=[O:16])[CH:5]=[CH:6][C:7]=1[N:8]1[CH:12]=[C:11]([Cl:13])[CH:10]=[N:9]1.[Na+:23]

Participants

3

Reactant 2

HCID 516892Sodium BicarbonateHCID 203034102-[3-Chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic acid

Product 1

HCID 23716984HCID 23716984, compoundYield 91.2%

Procedure

2.85 g (10 mmoles) of 2-[3-chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic acid are dissolved (on heating) in 10 ml of 1 N sodium hydrogen carbonate solution and extracted with diethyl ether; the aqueous phase is concentrated, the resulting residue is rubbed with chloroform and recrystallized from chloroform to yield 2.8 g (91.2% of theory) of sodium 2-[3-chloro-4-(4-chloropyrazol-1-yl)phenyl]propionate (m.p. 115° to 128° C.).

Workup

  1. extractionextracted with diethyl ether
  2. concentrationthe aqueous phase is concentrated
  3. customrecrystallized from chloroform

Sources & evidence

ORD record
ord-77ffbeec8ff64100b90a420f22c6918c
Source dataset
uspto-grants-1980_12
Patent number
US04239901

Reaction notes

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