HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 2-[3-Chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic hydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-[3-Chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic acid ethyl ester | HCID 53994550 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-[3-Chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic hydrazide | HCID 20303453 | — |
Reaction Steps
To a solution of 3.13 g (10 mmoles) of 2-[3-chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic acid ethyl ester in 20 ml of dimethyl formamide there are added dropwise, at room temperature, 15 ml of hydrazine hydrate. Stirring is continued for a further 2 hours at room temperature, followed by pouring on to ice, extraction with methylene chloride, drying of the organic phase and concentration. 2-[3-chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic hydrazide is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04239901 |
| Source dataset | uspto-grants-1980_12 |
| ORD ID | ord-af8a77639e9d47ea94cf177211d147b6 |
| Source note | uspto-grants-1980_12 |